| | |  | | | | Record from Web of Science® | | | | | | |
| Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice |
|
|
| Author(s): Gilhar A, Ullmann Y, Berkutzki T, Assy B, Kalish RS |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 101 Issue: 1 Pages: 62-67 Published: JAN 1 1998 |
| Times Cited: 95 References: 20 |
| Abstract: Alopecia areata is a tissue-restricted autoimmune disease of the hair follicle, which results in hair loss and baldness. It is often psychologically devastating. The role of T lymphocytes in this disorder was investigated with cell transfer experiments, Scalp explants from patients were transplanted to severe combined immunodeficiency (SCID) mice and injected with autologous T lymphocytes isolated from involved scalp. T lymphocytes which had been cultured with hair follicle homogenate along with antigen-presenting cells were capable of inducing the changes of alopecia areata, including hair loss and perifollicular infiltrates of T cells, along with HLA-DR and ICAM-1 expression of the follicular epithelium, Similar changes were not noted in grafts injected with scalp-derived T cells that had not been cultured with follicular homogenate, These data indicate that alopecia areata is mediated by T cells which recognize a follicular autoantigen. |
| Document Type: Article |
| Language: English |
| Reprint Address: Gilhar, A (reprint author), Technion Israel Inst Technol, Skin Res Lab, Fac Med, POB 9649, IL-31096 Haifa, Israel |
Addresses:
1. Technion Israel Inst Technol, Skin Res Lab, Fac Med, IL-31096 Haifa, Israel
2. SUNY Stony Brook, Dept Dermatol, Stony Brook, NY 11794 USA
3. Vet Affairs Med Ctr, Northport, NY 11768 USA |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: YQ513 |
| ISSN: 0021-9738 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |