| | |  | | | | Record from Web of Science® | | | | | | |
| Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas |
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| Author(s): Robertson FM, Parrett ML, Joarder FS, Ross M, Abou-Issa HM, Alshafie G, Harris RE |
| Source: CANCER LETTERS Volume: 122 Issue: 1-2 Pages: 165-175 Published: JAN 9 1998 |
| Times Cited: 63 References: 40 |
| Abstract: A single dose of 75 mg/kg 7,12 dimethylbenz[a]anthracene was administered to 50-day-old virgin female Sprague-Dawley rats and 100 days later, animals were randomized and provided with Teklad rodent chow mixed with a dose of 25 mg/rat/day ibuprofen for 35 days, Ibuprofen treatment reduced tumor volume (P < 0.05) and significantly inhibited gene expression of both cyclooxygenase-l and cyclooxygenase-2 (P < 0.02). These results indicate that ibuprofen induced significant regression of established mammary carcinomas which was associated with inhibition of expression of isoforms of the gene responsible for prostaglandin production. (C) 1998 Elsevier Science ireland Ltd. |
| Document Type: Article |
| Language: English |
| Reprint Address: Robertson, FM (reprint author), Ohio State Univ, Dept Med Microbiol & Immunol, Comprehens Canc Ctr 302B, 410 W 12th Ave, Columbus, OH 43210 USA |
Addresses:
1. Ohio State Univ, Dept Med Microbiol & Immunol, Comprehens Canc Ctr 302B, Columbus, OH 43210 USA
2. Ohio State Univ, Sch Publ Hlth, Ctr Comprehens Canc, Columbus, OH 43210 USA
3. Ohio State Univ, Coll Med & Publ Hlth, Dept Surg, Columbus, OH 43210 USA |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Oncology |
| IDS Number: YQ887 |
| ISSN: 0304-3835 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |