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| Differential expression of BCL-6, CD138/Syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas |
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| Author(s): Carbone A, Gaidano G, Gloghini A, Larocca LM, Capello D, Canzonieri V, Antinori A, Tirelli U, Falini B, Dalla-Favera R |
| Source: BLOOD Volume: 91 Issue: 3 Pages: 747-755 Published: FEB 1 1998 |
| Times Cited: 92 References: 45 |
| Abstract: This study was aimed at defining the histogenesis of the pathologic spectrum of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas (AIDS-NHL), including AIDS-related smalt noncleaved cell lymphoma (AIDS-SNCCL), AIDS-related large noncleaved cell lymphoma (AIDS-LNCCL), AIDS-related large cell immunoblastic lymphoma plasmacytoid (AIDS-IBLP), and AIDS-related primary effusion lymphoma (AIDS-PEL). Forty-six cases of AIDS-NHL were investigated for the expression pattern of BCL-6, a protein specifically expressed by germinal center (GC) B-cells, and CD138/syndecan-1 (syn-1), a marker of post-GC B-cell differentiation. Expression of BCL-6 and syn-1 segregated two major phenotypic patterns among AIDS-NHL: (1) the BCL-6(+)/syn-1(-) pattern associated with AIDS-SNCCL and AIDS-LNCCL; (2) the BCL-6(-)/syn-1(+) pattern associated with AIDS-IBLP and AIDS-PEL. Among systemic AIDS-NHL infected by Epstein-Barr virus (EBV), expression of the EBV-encoded latent membrane protein-1 (LMP-1) preferentially associated with the BCL-6(-)/syn-1(+) profile. Analysis of nonneoplastic lymph nodes showed that the two phenotypic patterns detected in AIDS-NHL correspond to physiologic stages of B-cell development, ie, GC B-cells (BCL-6(+)/syn-1(-)) and preterminally differentiated post-GC B-cells (BCL-6(-)/syn-1(+)). Thus, BCL-6(+)/syn-1(-) AIDS-NHL reflects a GC stage of differentiation, whereas AIDS-NHL which are BCL-6(-)/syn-1(+), and LMP-1(+) when infected by EBV, derive from B cells that have entered post-GC plasmacell differentiation. These findings are relevant for the pathogenesis and differential diagnosis of AIDS-NHL. (C) 1998 by The American Society of Hematology. |
| Document Type: Article |
| Language: English |
| Reprint Address: Carbone, A (reprint author), IRCCS, Ctr Riferimento Oncol, Div Pathol, Via Pedemontana Occidentale, I-33081 Aviano, Italy |
Addresses:
1. Carattere Sci, Ist Nazl Ricovero & Cura, Ctr Riferimento Oncol, Div Pathol, Aviano, Italy
2. Carattere Sci, Ist Nazl Ricovero & Cura, Ctr Riferimento Oncol, Div Med Oncol, Aviano, Italy
3. Carattere Sci, Ist Nazl Ricovero & Cura, Ctr Riferimento Oncol, AIDS Program, Aviano, Italy
4. Univ Turin, Dept Med Sci, Div Internal Med, Novara, Italy
5. Univ Cattolica Sacro Cuore, Inst Pathol, Rome, Italy
6. Univ Cattolica Sacro Cuore, Inst Infect Dis, Rome, Italy
7. Univ Perugia, Inst Hematol, I-06100 Perugia, Italy
8. Columbia Univ Coll Phys & Surg, Dept Pathol, Div Oncol, New York, NY 10032 USA |
| Publisher: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA |
| Subject Category: Hematology |
| IDS Number: YT777 |
| ISSN: 0006-4971 |
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