| | |  | | | | Record from Web of Science® | | | | | | |
| Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis |
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| Author(s): Clynes R, Dumitru C, Ravetch JV |
| Source: SCIENCE Volume: 279 Issue: 5353 Pages: 1052-1054 Published: FEB 13 1998 |
| Times Cited: 339 References: 42 |
| Abstract: The generation of autoantibody and subsequent tissue deposition of immune complexes (IC) is thought to trigger the pathogenic consequences of systemic autoimmune disease. Modulation of the autoantibody response disrupts pathogenesis by preventing the formation of ICs; however, uncoupling IC formation from subsequent inflammatory responses seems unlikely because of the apparent complexity of the IC-triggered inflammatory cascade. However, the disruption of a single gene, which encodes the gamma chain of the Fc receptor, was found to achieve this uncoupling in a spontaneous model of lupus nephritis, the New Zealand Black/New Zealand White (NZB/NZW) mouse. Gamma chain-deficient NZB/NZW mice generated and deposited IC and activated complement, but were protected from severe nephritis, thus defining another potential pathway for therapeutic intervention in autoimmune disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ravetch, JV (reprint author), Rockefeller Univ, Mol Genet & Immunol Lab, New York, NY 10021 USA |
Addresses:
1. Rockefeller Univ, Mol Genet & Immunol Lab, New York, NY 10021 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: YX100 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |