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| Novel nuclear phosphoprotein pp32 is highly expressed in intermediate- and high-grade prostate cancer |
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| Author(s): Kadkol SS, Brody JR, Epstein JI, Kuhajda FP, Pasternack GR |
| Source: PROSTATE Volume: 34 Issue: 3 Pages: 231-237 Published: FEB 15 1998 |
| Times Cited: 38 References: 28 |
| Abstract: BACKGROUND. pp32 is a differentiation-regulated nuclear phosphoprotein that is highly expressed in many cancers, but is restricted to self-renewing and long-lived normal cell populations. During murine embryogenesis, pp32 is expressed in primitive cell populations, diminishing as tissues terminally differentiate. Functionally, pp32 confers resistance to programmed cell death and, paradoxically, inhibits transformation mediated in vitro by a broad range of oncogenes, suggesting that pp32 is a multifunctional molecule with potentially complex activities in cancer. METHODS. We studied pp32 expression in prostatic adenocarcinomas and benign prostatic hyperplasia by in situ hybridization.
RESULTS. In benign prostatic tissues, moderate pp32 expression occurs only in the basal cells. This study found elevated pp32 expression in 98% (54/55) of prostatic adenocarcinomas of Gleason score greater than or equal to 5 (P < 0.0001).
CONCLUSIONS. These results suggest that pp32 may be diagnostically useful and may contribute mechanistically to prostate tumor development. In comparison to other molecular alterations, increased pp32 expression is one of the most frequent events in primary prostate cancer. (C) 1998 Wiley-Liss, Inc.
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| Document Type: Article |
| Language: English |
| Reprint Address: Pasternack, GR (reprint author), Johns Hopkins Univ, Sch Med, Dept Pathol, Div Mol Pathol, 512 Ross,720 Rutland Ave, Baltimore, MD 21205 USA |
Addresses:
1. Johns Hopkins Univ, Sch Med, Dept Pathol, Div Mol Pathol, Baltimore, MD 21205 USA
2. Johns Hopkins Univ, Sch Med, Dept Pathol, Div Surg Pathol, Baltimore, MD 21205 USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA |
| Subject Category: Endocrinology & Metabolism; Urology & Nephrology |
| IDS Number: YY584 |
| ISSN: 0270-4137 |
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