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| Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior |
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| Author(s): Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JRS, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M |
| Source: CELL Volume: 92 Issue: 4 Pages: 573-585 Published: FEB 20 1998 |
| Times Cited: 1,665 References: 57 |
| Abstract: The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior. |
| Document Type: Article |
| Language: English |
| Reprint Address: Yanagisawa, M (reprint author), Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dept Mol Genet, Dallas, TX 75235 USA |
Addresses:
1. Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dept Mol Genet, Dallas, TX 75235 USA
2. Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA
3. Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75235 USA
4. Univ Texas, SW Med Ctr, Dept Physiol, Dallas, TX 75235 USA
5. SmithKline Beecham Pharmaceut, Harlow CM19 5AD, Essex England
6. SmithKline Beecham Pharmaceut, King Of Prussia, PA 19406 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: YZ409 |
| ISSN: 0092-8674 |
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