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| Prognosis in malignant mesothelioma related to MIB 1 proliferation index and histological subtype |
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| Author(s): Beer TW, Buchanan R, Matthews AW, Stradling R, Pullinger N, Pethybridge RJ |
| Source: HUMAN PATHOLOGY Volume: 29 Issue: 3 Pages: 246-251 Published: MAR 1998 |
| Times Cited: 27 References: 34 |
| Abstract: The aims of this study were to evaluate the use of the proliferation marker MIB 1 and histological subtype as indicators of prognosis in malignant mesothelioma. Sections from 41 cases of malignant mesothelioma were histologically subtyped on hematoxylin and eosin sections and stained immunohistochemically for the proliferation marker MIB 1, A proliferation index was derived and the results compared with patient survival data. A statistically significant difference was found between the survival of patients having in low and high MIB 1 index (P < .001). Patients with tumors having a low MIB 1 index lived significantly longer than those with a high MIB 1 index. Patients with the spindle cell histological subtype of malignant mesothelioma had significantly shorter survival times than those with the epithelioid or mixed tumors (P < .01). The MIB 1 proliferation index and histological tumor subtype are useful markers of prognosis in malignant mesothelioma. Copyright (C) 1998 by W.B. Saunders Company. |
| Document Type: Article |
| Language: English |
| Reprint Address: Beer, TW (reprint author), Royal Hosp, Dept Histopathol, Haslar PO12 2AA, Hants England |
Addresses:
1. Royal Hosp, Dept Histopathol, Haslar PO12 2AA, Hants England
2. Queen Alexandra Hosp, Dept Histopathol, Portsmouth, Hants England
3. Queen Alexandra Hosp, Dept Thorac Med, Portsmouth, Hants England
4. Inst Naval Med, Gosport PO12 2DL, Hants England |
| Publisher: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA |
| Subject Category: Pathology |
| IDS Number: YZ606 |
| ISSN: 0046-8177 |
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