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| Stromelysin 3: An independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression |
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| Author(s): Ahmad A, Hanby A, Dublin E, Poulsom R, Smith P, Barnes D, Rubens R, Anglard P, Hart I |
| Source: AMERICAN JOURNAL OF PATHOLOGY Volume: 152 Issue: 3 Pages: 721-728 Published: MAR 1998 |
| Times Cited: 65 References: 33 |
| Abstract: Stromelysin 3 (ST3) is a matrix metalloproteinase implicated in mammary carcinoma progression. To date, localization of ST3 expression in breast cancer by in situ hybridization and immunocytochemistry has shown that the expression of the enzyme is limited to only the stromal fibroblasts surrounding the cancer cells. We have immunostained a large group of ductal carcinoma in situ and invasive breast carcinomas using a monoclonal antibody (5ST-4A9) raised against the hemopexin-like domain of human ST3. We show that invasive lobular carcinomas express significantly less ST3 than Invasive ductal carcinomas (IDCs) (P = 0.002). We also show, for the first time, that certain breast carcinoma cells that have undergone a degree of epithelial-to-mesenchymal transition, the so-called metaplastic carcinomas, can express ST3 mRNA and protein, which may in part explain the increased metastatic propensity seen in a number of these tumors. In addition, patients with IDC who had moderate to strong ST3 levels had significantly shorter disease-free survival than those with negative or weak STS levels (P = 0.02). Furthermore, in node-positive IDC patients, multivariate analysis revealed that ST3 level was a strong, independent prognostic parameter for disease-free survival (P = 0.005). |
| Document Type: Article |
| Language: English |
| Reprint Address: Ahmad, A (reprint author), UMDS, Rayne Inst, Imperial Canc Res Fund, Richard Dimbleby Dept Canc Res, Lambeth Palace Rd, London SE1 7EH, England |
Addresses:
1. Inst Genet & Biol Mol & Cellulaire, Strasbourg, France
2. Imperial Canc Res Fund, Insitu Hybridisat Serv, London WC2A 3PX, England
3. Imperial Canc Res Fund, Histopathol Unit, London WC2A 3PX, England
4. Guys Hosp, Imperial Canc Res Fund, Clin Oncol Unit, London SE1 9RT, England
5. St Thomas Hosp, Rayne Inst, Imperial Canc Res Fund, Richard Dimbleby Dept Canc Res, London SE1 7EH, England |
| Publisher: AMER SOC INVESTIGATIVE PATHOLOGY, INC, 428 EAST PRESTON ST, BALTIMORE, MD 21202-3993 USA |
| Subject Category: Pathology |
| IDS Number: ZA191 |
| ISSN: 0002-9440 |
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