| | |  | | | | Record from Web of Science® | | | | | | |
| Muscle regeneration by bone marrow derived myogenic progenitors |
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| Author(s): Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F |
| Source: SCIENCE Volume: 279 Issue: 5356 Pages: 1528-1530 Published: MAR 6 1998 |
| Times Cited: 1,439 References: 20 |
| Abstract: Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers, In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sources. Transplantation of genetically marked bone marrow into Immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers, Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies. |
| Document Type: Article |
| Language: English |
| Reprint Address: Cossu, G (reprint author), Univ Rome La Sapienza, Dipartimento Istol & Embriol Med, Piazzale Aldo Moro 5, I-00161 Rome, Italy |
Addresses:
1. Univ Rome La Sapienza, Dipartimento Istol & Embriol Med, I-00161 Rome, Italy
2. Hosp San Raffaele, Telethon Inst Gene Therapy, I-20132 Milan, Italy
3. Univ Pavia, Ist Anat Umana Normale, I-27100 Pavia, Italy |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: ZA527 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |