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| A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test |
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| Author(s): Spielman RS, Ewens WJ |
| Source: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 62 Issue: 2 Pages: 450-458 Published: FEB 1998 |
| Times Cited: 414 References: 16 |
| Abstract: Linkage analysis with genetic markers has been successful in the localization of genes for many monogenic human diseases. In studies of complex diseases, however, tests that rely on linkage disequilibrium (the simultaneous presence of linkage and association) are often more powerful than those that rely on linkage alone. This advantage is illustrated by the transmission/disequilibrium test (TDT). The TDT requires data (marker genotypes) for affected individuals and their parents; for some diseases, however, data from parents may be difficult or impossible to obtain. In this article, we describe a method, called the "sib TDT" (or "S-TDT"), that overcomes this problem by use of marker data from unaffected sibs instead of from parents, thus allowing application of the principle of the TDT to sibships without parental data. In a single collection of families, there might be some that can be analyzed only by the TDT and others that are suitable for analysis by the S-TDT. We show how all the data may be used jointly in one overall TDT-type procedure that tests for linkage in the presence of association, These extensions of the TDT will be valuable for the study of diseases of late onset, such as non-insulin-dependent diabetes, cardiovascular diseases, and other diseases associated with aging. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ewens, WJ (reprint author), Univ Penn, Dept Biol, Philadelphia, PA 19104 USA |
Addresses:
1. Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
2. Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA |
| Publisher: UNIV CHICAGO PRESS, 5801 S ELLIS AVENUE, CHICAGO, IL 60637 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: ZA927 |
| ISSN: 0002-9297 |
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