| | |  | | | | Record from Web of Science® | | | | | | |
| Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53 |
|
|
| Author(s): Cote RJ, Dunn MD, Chatterjee SJ, Stein JP, Shi SR, Tran QC, Hu SX, Xu HJ, Groshen S, Taylor CR, Skinner DG, Benedict WF |
| Source: CANCER RESEARCH Volume: 58 Issue: 6 Pages: 1090-1094 Published: MAR 15 1998 |
| Times Cited: 200 References: 20 |
| Abstract: Rb protein (pRb) expression was evaluated in 185 cases of transitional cell carcinoma of the bladder from patients that underwent radical cystectomy, Tumors were stratified into three categories based on the percentage of nuclei expressing pRb: (a) 0, 0% of tumor cells showing nuclear reactivity; (b) 1+, 1-50% of tumor cells showing nuclear reactivity; and (c) 2+, > 50% of tumor cells showing nuclear reactivity. Cases with undetectable (pRb 0) and high (pRb 2+) pRb reactivity had identical rates of recurrence. These cases had significantly higher recurrence (P = 0.0001) and loser survival rates (P = 0.0002) compared to cases with moderate (pRb 1+) pRb reactivity. indicating that high levels of pRb expression may reflect a dysfunctional (altered) Rb pathway, The tumors were also examined for alterations in p53 expression; patients with tumors altered in both p53 and pRb had significantly increased rates of recurrence (P < 0.0001) and survival (P < 0.0001) compared to patients with no alterations in either p53 or pRb; patients with alterations in only one of these proteins had intermediate rates of recurrence and survival. These results suggest that: (a) bladder cancers,vith high pRb expression do not show the tumor suppressor effects of the protein; and (bi alteration in both p53 and pRb may act in cooperative or synergistic ways to promote tumor progression. |
| Document Type: Article |
| Language: English |
| Reprint Address: Cote, RJ (reprint author), Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Sch Med, Dept Pathol, 1441 Eastlake Ave, Los Angeles, CA 90033 USA |
Addresses:
1. Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Sch Med, Dept Pathol, Los Angeles, CA 90033 USA
2. Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
3. Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Sch Med, Dept Urol, Los Angeles, CA 90033 USA
4. MD Anderson Canc Ctr, Dept Hematol, The Woodlands, TX 77381 USA
5. MD Anderson Canc Ctr, Dept Mol Oncol, The Woodlands, TX 77381 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA |
| Subject Category: Oncology |
| IDS Number: ZB892 |
| ISSN: 0008-5472 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |