| | |  | | | | Record from Web of Science® | | | | | | |
| Dendritic cells and the control of immunity |
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| Author(s): Banchereau J, Steinman RM |
| Source: NATURE Volume: 392 Issue: 6673 Pages: 245-252 Published: MAR 19 1998 |
| Times Cited: 6,692 References: 103 |
| Abstract: B and T lymphocytes are the mediators of Immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses, They not only activate lymphocytes, they also tolerize T cells to antigens that are Innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis, With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system. |
| Document Type: Review |
| Language: English |
| Reprint Address: Banchereau, J (reprint author), Baylor Res Inst, Baylor Inst Immunol, 3409 Worth St, Dallas, TX 75246 USA |
Addresses:
1. Baylor Res Inst, Baylor Inst Immunol, Dallas, TX 75246 USA
2. Rockefeller Univ, Cellular Physiol & Immunol Lab, New York, NY 10021 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: ZC739 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |