| | |  | | | | Record from Web of Science® | | | | | | |
| Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function |
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| Author(s): Walker D, De Waard M |
| Source: TRENDS IN NEUROSCIENCES Volume: 21 Issue: 4 Pages: 148-154 Published: APR 1998 |
| Times Cited: 263 References: 98 |
| Abstract: Voltage-dependent Ca2+ channels are heteromeric complexes found in the plasma membrane of virtually all cell types and show a high level of electrophysiological and pharmacological diversity.; Associated with the pore-forming alpha l subunit are the membrane anchored, largely extracellular alpha 2-delta, the cytoplasmic beta and sometimes a transmembrane gamma subunit; these subunits dramatically influence the properties and surface expression of these channels. Effects vary depending on subunit isoforms, suggesting that functional diversity of native channels reflects heterogeneity of combinations. Interaction sites between subunits have been identified and advances have been made in our understanding of the molecular basis of functional effects of the auxiliary subunits, their capacity to be regulated by G proteins, and their interaction with related cellular systems. |
| Document Type: Review |
| Language: English |
| Reprint Address: Walker, D (reprint author), Fac Med Nord, Inst Federat Jean Roche, INSERM U464, Lab Neurobiol Canaux Ion, Blvd Pierre Dramard, F-13916 Marseille 20, France |
Addresses:
1. Fac Med Nord, Inst Federat Jean Roche, INSERM U464, Lab Neurobiol Canaux Ion, F-13916 Marseille 20, France |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND |
| Subject Category: Neurosciences |
| IDS Number: ZE669 |
| ISSN: 0166-2236 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |