| | |  | | | | Record from Web of Science® | | | | | | |
| Ceramide signaling in apoptosis |
|
|
| Author(s): Haimovitz-Friedman A, Kolesnick RN, Fuks Z |
| Source: BRITISH MEDICAL BULLETIN Volume: 53 Issue: 3 Pages: 539-553 Published: 1997 |
| Times Cited: 86 References: 57 |
| Abstract: The sphingomyelin pathway is a ubiquitous, evolutionarily conserved signa ii ng system initiated by hydrolysis of the plasma membrane phospholipid sphingomyelin to generate ceramide. Ceramide acts as a second messenger in activating the apoptotic cascade. Diverse cytokine receptors and environmental stresses utilize ceramide to signal apoptosis. In several cell systems ceramide links to the stress-activated protein kinase (SAPK)/c-jun kinase (JNK) cascade to signal apoptosis. The engagement of the sphingomyelin pathway in signaling apoptosis is tightly regulated by anti-apoptotic central mechanisms, and the balance between pro- and anti-apoptotic systems determines the magnitude of the apoptotic response in vitro and in vivo. This review describes the known elements and molecular ordering of ceramide-mediated apoptosis and the anti-apoptotic mechanisms that regulate its expression. Understanding of pro- and anti-apoptotic signaling involved in ceramide-mediated apoptosis and the modes of their co-ordinated Function may yield opportunities for pharmacological interventions with potential for clinical applications. |
| Document Type: Article |
| Language: English |
| Reprint Address: Haimovitz-Friedman, A (reprint author), Mem Sloan Kettering Canc Ctr, Radiat Oncol Labs, Dept Radiat Oncol, 1275 York Ave, New York, NY 10021 USA |
Addresses:
1. Mem Sloan Kettering Canc Ctr, Radiat Oncol Labs, Dept Radiat Oncol, New York, NY 10021 USA
2. Mem Sloan Kettering Canc Ctr, Lab Signal Transduct, New York, NY 10021 USA |
| Publisher: ROYAL SOC MEDICINE PRESS LTD, 1 WIMPOLE STREET, LONDON W1M 8AE, ENGLAND |
| Subject Category: Medicine, General & Internal |
| IDS Number: ZF939 |
| ISSN: 0007-1420 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |