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| Conditioning factors in drug abuse: can they explain compulsion? |
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| Author(s): O'Brien CP, Childress AR, Ehrman R, Robbins SJ |
| Source: JOURNAL OF PSYCHOPHARMACOLOGY Volume: 12 Issue: 1 Pages: 15-22 Published: MAR 1998 |
| Times Cited: 207 References: 63 |
| Abstract: There is a good deal of clinical evidence suggesting that compulsion to resume drug taking is an important part of the addiction syndrome. The symptoms comprising motivation to resume drug use, namely craving and compulsion, have been studied experimentally in human subjects. While much work remains to be done, there is evidence showing that these symptoms are influenced by learning. The research has been guided by animal studies demonstrating that drug effects can be conditioned. Much attention has been directed toward demonstrating the existence of drug conditioning in human addicts and exploring the neurological structures that may underlie such learned responses,We do not yet know the relative importance of learning in the overall phenomenon of relapse, and treatments based on conditioning principles are still under investigation. |
| Document Type: Article |
| Language: English |
| Reprint Address: O'Brien, CP (reprint author), Univ Penn, Vet Affairs Med Ctr, 3900 Chestnut St, Philadelphia, PA 19104 USA |
Addresses:
1. Univ Penn, Vet Affairs Med Ctr, Philadelphia, PA 19104 USA |
| Publisher: SAGE PUBLICATIONS LTD, 6 BONHILL STREET, LONDON, ENGLAND EC2A 4PU |
| Subject Category: Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry |
| IDS Number: ZH321 |
| ISSN: 0269-8811 |
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