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| Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3 |
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| Author(s): Jussila L, Valtola R, Partanen TA, Salven P, Heikkila P, Matikainen MT, Renkonen R, Kaipainen A, Detmar M, Tschachler E, Alitalo R, Alitalo K |
| Source: CANCER RESEARCH Volume: 58 Issue: 8 Pages: 1599-1604 Published: APR 15 1998 |
| Times Cited: 189 References: 24 |
| Abstract: Lymphatic vessels have been difficult to study in detail in normal and tumor tissues because of the lack of molecular markers. sere, monoclonal antibodies against the extracellular domain of the vascular endothelial growth factor-C receptor that we have named VEGFR-3 were found to specifically stain endothelial cells of lymphatic vessels and vessels around tumors such as lymphoma and in situ breast carcinoma, Interestingly, the spindle cells of several cutaneous nodular AIDS-associated Kaposi's sarcomas and the endothelium around the nodules were also VEGFR-3 positive. The first specific molecular marker for the lymphatic endothelium should provide a useful tool for the analysis of lymphatic vessels in malignant tumors and their metastases and the cellular origin and differentiation of Kaposi's sarcomas. |
| Document Type: Article |
| Language: English |
| Reprint Address: Alitalo, K (reprint author), Univ Helsinki, Mol Canc Biol Lab, Haartman Inst, FIN-00014 Helsinki, Finland |
Addresses:
1. Univ Helsinki, Mol Canc Biol Lab, Haartman Inst, FIN-00014 Helsinki, Finland
2. Univ Helsinki, Dept Pathol, Haartman Inst, FIN-00014 Helsinki, Finland
3. Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, FIN-00014 Helsinki, Finland
4. Univ Helsinki, Transplantat Lab, Haartman Inst, FIN-00014 Helsinki, Finland
5. Univ Turku, Ctr Biotechnol, FIN-20520 Turku, Finland
6. Univ Helsinki, Cent Hosp, Dept Oncol, FIN-00290 Helsinki, Finland
7. Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA
8. Harvard Univ, Sch Med, Charlestown, MA 02129 USA
9. Univ Vienna, Dept Dermatol, A-1090 Vienna, Austria |
| Publisher: AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA |
| Subject Category: Oncology |
| IDS Number: ZH644 |
| ISSN: 0008-5472 |
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