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| Selective expression of inducible nitric oxide synthase in human prostate carcinoma |
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| Author(s): Klotz T, Bloch W, Volberg C, Engelmann U, Addicks K |
| Source: CANCER Volume: 82 Issue: 10 Pages: 1897-1903 Published: MAY 15 1998 |
| Times Cited: 107 References: 22 |
| Abstract: BACKGROUND. Nitric oxide (NO) is synthesized by inducible nitric oxide synthase (iNOS) and plays an important role in tumor growth and angiogenesis. NO generation by NOS also influences the cytotoxicity of macrophages and tumor-induced immunosuppression. Before now, the expression of iNOS in prostate carcinoma tissue had not been determined. METHODS. In this study, tissue sections from 16 patients with prostate carcinoma were studied immunohistochemically and compared with tissue specimens from 10 patients with benign hyperplasia.
RESULTS. Positive iNOS immunostaining was detected in all sections from patients with prostate carcinoma. The malignant epithelial cells were highly positive. The antibody against iNOS also marked round cells, which had the same cell shape as that observed for macrophages. These cells were located in stroma and epithelium adjacent to tumor islets. However, round cells in benign tissue stained negative for iNOS. None of the benign hyperplasia specimens stained positive for iNOS immunohistochemically.
CONCLUSIONS. Prostate carcinoma tissue had a high iNOS content, whereas benign tissue did not. The authors suggest that epithelial iNOS expression can be used as a specific immunohistochemical marker for prostate carcinoma. NO generation by iNOS may play multiple roles in the development of this disease. (C) 1998 American Cancer Society.
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| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Klotz, T (reprint author), Univ Cologne, Dept Urol, Joseph Stelzmann Str 9, D-50924 Cologne, Germany |
Addresses:
1. Univ Cologne, Dept Urol, D-50924 Cologne, Germany
2. Univ Cologne, Dept Anat, Cologne, Germany |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA |
| Subject Category: Oncology |
| IDS Number: ZL108 |
| ISSN: 0008-543X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |