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| Comparison of alopecia areata in human and nonhuman mammalian species |
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| Author(s): McElwee KJ, Boggess D, Olivry T, Oliver RF, Whiting D, Tobin DJ, Bystryn JC, King LE, Sundberg JP |
| Source: PATHOBIOLOGY Volume: 66 Issue: 2 Pages: 90-107 Published: MAR-APR 1998 |
| Times Cited: 38 References: 157 |
| Abstract: Alopecia areata (AA) is a nonscarring form of inflammatory hair loss in humans, AA-like hair loss has also been observed in other species. In recent years the Dundee experimental bald rat and the C3H/HeJ mouse have been put forward as models for human AA, AA in all species presents with a wide range of clinical features from focal, locally extensive, diffuse hair loss, to near universal alopecia, Histologically, all species have dystrophic anagen stage hair follicles associated with a peri- and intrafollicular inflammatory cell infiltrate, Autoantibodies directed against anagen stage hair follicle structures are a consistent finding. Observations on AA pathogenesis suggest nonhuman species can provide excellent models for the human disease. Ultimately, animal models will be used to determine the genetic basis of AA, potential endogenous and/or environmental trigger(s), mechanism(s) of disease initiation and progression, and allow rapid evaluation of new and improved disease treatments. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sundberg, JP (reprint author), Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA |
Addresses:
1. Jackson Lab, Bar Harbor, ME 04609 USA
2. N Carolina State Univ, Coll Vet Med, Dept Compan Anim & Special Species Med, Raleigh, NC USA
3. Dallas Associated Dermatologists, Dallas, TX USA
4. NYU, Dept Dermatol, New York, NY 10016 USA
5. Vanderbilt Univ, Dept Dermatol, Nashville, TN USA
6. Univ Dundee, Dept Biol Sci, Dundee DD1 4HN, Scotland
7. Univ Bradford, Dept Biomed Sci, Bradford BD7 1DP, W Yorkshire England |
| Publisher: KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND |
| Subject Category: Cell Biology; Pathology |
| IDS Number: ZR445 |
| ISSN: 1015-2008 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |