| | |  | | | | Record from Web of Science® | | | | | | |
| The C-elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters |
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| Author(s): Wu YC, Horvitz HR |
| Source: CELL Volume: 93 Issue: 6 Pages: 951-960 Published: JUN 12 1998 |
| Times Cited: 159 References: 64 |
| Abstract: The C. elegans gene ced-7 functions in the engulfment of cell corpses during programmed cell death. We report that the CED-7 protein has sequence similarity to ABC transporters, is broadly expressed during embryogenesis, and is localized to the plasma membrane. Mosaic analysis revealed that ced-7 functions in both dying cells and engulfing cells during the engulfment process. We propose that CED-7 functions to translocate molecules that mediate homotypic adhesion between the cell surfaces of the dying and engulfing cells. Like CED-7, the mammalian ABC transporter ABC1 has been implicated in the engulfment of cell corpses, suggesting that CED-7 and ABC1 may be functionally similar and that the molecular mechanism underlying cell corpse engulfment during programmed cell death may be conserved from nematodes to mammals. |
| Document Type: Article |
| Language: English |
| Reprint Address: Horvitz, HR (reprint author), MIT, Dept Biol, Howard Hughes Med Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA |
Addresses:
1. MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: ZU514 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |