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| Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy |
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| Author(s): Mir LM, Glass LF, Sersa G, Teissie J, Domenge C, Miklavcic D, Jaroszeski MJ, Orlowski S, Reintgen DS, Rudolf Z, Belehradek M, Gilbert R, Rols MP, Belehradek J, Bachaud JM, DeConti R, Stabuc B, Cemazar M, Coninx P, Heller R |
| Source: BRITISH JOURNAL OF CANCER Volume: 77 Issue: 12 Pages: 2336-2342 Published: JUN 1998 |
| Times Cited: 189 References: 31 |
| Abstract: Electrochemotherapy (ECT) enhances the effectiveness of chemotherapeutic agents by administering the drug in combination with short intense electric pulses. ECT is effective because electric pulses permeabilize tumour cell membranes and allow non-permeant drugs, such as bleomycin, to enter the cells. The aim of this study was to demonstrate the anti-tumour effectiveness of ECT with bleomycin on cutaneous and subcutaneous tumours. This article summarizes results obtained in independent clinical trials performed by five cancer centres, A total of 291 cutaneous or subcutaneous tumours of basal cell carcinoma (32), malignant melanoma (142), adenocarcinoma (30) and head and neck squamous cell carcinoma (87) were treated in 50 patients. Short and intense electric pulses were applied to tumours percutaneously after intravenous or intratumour administration of bleomycin. The rumours were measured and the response to the treatment evaluated 30 days after the treatment. Objective responses were obtained in 233 (85.3%) of the 273 evaluable tumours that were treated with ECT. Clinical complete responses were achieved in 154 (56.4%) tumours, and partial responses were observed in 79 (28.9%) tumours. The application of electric pulses to the patients was safe and well tolerated. An instantaneous contraction of the underlying muscles was noticed. Minimal adverse side-effects were observed. ECT was shown to be an effective local treatment. ECT was effective regardless of the histological type of the tumour, Therefore, ECT offers an approach to the treatment of cutaneous and subcutaneous tumours in patients with minimal adverse side-effects and with a high response rate. |
| Document Type: Article |
| Language: English |
| Reprint Address: Mir, LM (reprint author), Inst Gustave Roussy, URA 147 CNRS, LPPMB Biochim Enzymol, 39 Rue Camille Desmoulins, F-94805 Villejuif, France |
Addresses:
1. Inst Gustave Roussy, URA 147 CNRS, LPPMB Biochim Enzymol, F-94805 Villejuif, France
2. Univ S Florida, Dept Internal Med, Tampa, FL 33612 USA
3. H Lee Moffitt Canc Ctr, Cutaneous Oncol Program, Tampa, FL 33612 USA
4. Res Inst, Tampa, FL 33612 USA
5. Inst Oncol, SL-1105 Ljubljana, Slovenia
6. CNRS, UPR 8221, LPTF, F-31062 Toulouse, France
7. Inst Gustave Roussy, Dept Head & Neck Carcinol, F-94805 Villejuif, France
8. Univ Ljubljana, Fac Elect Engn, SL-1000 Ljubljana, Slovenia
9. Univ S Florida, Dept Surg, Tampa, FL 33612 USA
10. CEN Saclay, URA 2096 CNRS, CEA, DBCM,SBPM, F-91191 Gif Sur Yvette, France
11. Univ S Florida, Dept Chem Engn, Tampa, FL 33612 USA
12. Ctr Claudius Regaud, Dept Radiotherapy, F-31052 Toulouse, France
13. Inst Jean Godinot, Dept Head & Neck Carcinol, F-51056 Reims, France |
| Publisher: CHURCHILL LIVINGSTONE, JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND |
| Subject Category: Oncology |
| IDS Number: ZU851 |
| ISSN: 0007-0920 |
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