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| Apoptosis: The importance of being eaten |
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| Author(s): Ren Y, Savill J |
| Source: CELL DEATH AND DIFFERENTIATION Volume: 5 Issue: 7 Pages: 563-568 Published: JUL 1998 |
| Times Cited: 217 References: 65 |
| Abstract: In vivo, cells undergoing apoptosis are usually recognised and swiftly ingested by macrophages or neighbouring cells acting as semi-professional phagocytes, This review debates evidence that the contents of apoptotic cells represent a danger to the organism, being capable of injuring tissue directly or triggering autoimmune responses, concluding that phagocytic clearance of intact apoptotic cells is a safe disposal route. Indeed, new data suggest that, in certain circumstances, phagocytes ingesting apoptotic cells may actively downregulate inflammatory and immune responses, Consequently, increasing evidence that there may be factors capable of perturbing safe clearance of apoptotic cells in vivo suggests that failure of this process may be a hitherto unrecognised pathogenetic factor in inflammatory and autoimmune diseases. New treatments designed to promote safe phagocytic clearance of dying cells can be anticipated, and it may even prove possible to eliminate unwanted cells by inducing appearance of cell surface 'eat me' signals. |
| Document Type: Review |
| Language: English |
| Reprint Address: Savill, J (reprint author), Univ Nottingham Hosp, Div Renal & Inflammatory Dis, Nottingham NG7 2UH, England |
Addresses:
1. Univ Nottingham Hosp, Div Renal & Inflammatory Dis, Nottingham NG7 2UH, England |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: ZW978 |
| ISSN: 1350-9047 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |