| | |  | | | | Record from Web of Science® | | | | | | |
| Mitochondria and apoptosis |
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| Author(s): Green DR, Reed JC |
| Source: SCIENCE Volume: 281 Issue: 5381 Pages: 1309-1312 Published: AUG 28 1998 |
| Times Cited: 4,829 References: 56 |
| Abstract: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death. |
| Document Type: Review |
| Language: English |
| Reprint Address: Green, DR (reprint author), La Jolla Inst Allergy & Immunol, 10355 Sci Ctr Dr, San Diego, CA 92121 USA |
Addresses:
1. La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA
2. Burnham Inst, La Jolla, CA 92037 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 115LQ |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |