| | |  | | | | Record from Web of Science® | | | | | | |
| Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21 |
|
|
| Author(s): Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, Lamacz M, Thomas MG, Gehrig C, Radhakrishna U, Snyder SE, Balk KG, Neufeld K, Swartz KL, DeMarchi N, Papadimitriou GN, Dikeos DG, Stefanis CN, Chakravarti A, Childs B, Housman DE, Kazazian HH, Antonarakis SE, Pulver AE |
| Source: NATURE GENETICS Volume: 20 Issue: 1 Pages: 70-73 Published: SEP 1998 |
| Times Cited: 350 References: 30 |
| Abstract: Schizophrenia is a common disorder characterized by psychotic symptoms; diagnostic criteria have been established(1). Family, twin and adoption studies suggest that both genetic and environmental factors influence susceptibility (heritability is approximately 71%; ref. 2), however, little is known about the aetiology of schizophrenia. Clinical and family studies suggest aetiological heterogeneity(3-6). Previously, we reported that regions on chromosomes 22, 3 and 8 may be associated with susceptibility to schizophrenia(7-8), and collaborations provided some support for regions on chromosomes 8 and 22 (refs 9-13). We present here a genome-wide scan for schizophrenia susceptibility loci (SSL) using 452 microsatellite markers on 54 multiplex pedigrees. Non-parametric linkage (NPL) analysis provided significant evidence for an SSL on chromosome 13q32 (NPL score=4.18; P=0.00002), and suggestive evidence for another SSL on chromosome 8p21-22 (NPL=3.64; P=0.0001). Parametric linkage analysis provided additional support for these SSL. Linkage evidence at chromosome 8 is weaker than that at chromosome 13, so it is more probable that chromosome 8 may be a false positive linkage. Additional putative SSL were noted on chromosomes 14q13 (NPL=2.57: P=0.005), 7q11 (NPL=2.50, P=0.007) and 22q11 (NPL=2.42, P=0.009). Verification of suggestive SSL on chromosomes 13q and 8p was attempted in a follow-up sample of 54 multiplex pedigrees. This analysis confirmed the SSL in 13q14-q33 (NPL=2.36, P=0.007) and supported the SSL in 8p22-p21 (NPL=1.95, P=0.023). |
| Document Type: Article |
| Language: English |
| Reprint Address: Pulver, AE (reprint author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21231 USA |
Addresses:
1. Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21231 USA
2. Univ Geneva, Sch Med, Div Med Genet, CH-1211 Geneva, Switzerland
3. Univ Geneva, Hop Cantonal, CH-1211 Geneva, Switzerland
4. Univ Penn, Dept Genet, Philadelphia, PA 19104 USA
5. Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA
6. Case Western Reserve Univ, Ctr Human Genet, Cleveland, OH 44106 USA
7. Univ Hosp Cleveland, Cleveland, OH 44106 USA
8. Univ Naples 2, Inst Psichiatria, I-80138 Naples, Italy
9. Univ Athens, Eginit Hosp, Mental Hlth Res Inst, GR-11528 Athens, Greece
10. MIT, Ctr Canc Res, Cambridge, MA 02139 USA |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 115NK |
| ISSN: 1061-4036 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |