| | |  | | | | Record from Web of Science® | | | | | | |
| Prevention of cardiac hypertrophy in mice by calcineurin inhibition |
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| Author(s): Sussman MA, Lim HW, Gude N, Taigen T, Olson EN, Robbins J, Colbert MC, Gualberto A, Wieczorek DF, Molkentin JD |
| Source: SCIENCE Volume: 281 Issue: 5383 Pages: 1690-1693 Published: SEP 11 1998 |
| Times Cited: 286 References: 29 |
| Abstract: Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin Light chain-2, or fetal beta-tropomyosin in the heart. Cyclosporin had a similar effect in a rat model of pressure-overload hypertrophy. These results suggest that calcineurin inhibitors merit investigation as potential therapeutics for certain forms of human heart disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: Molkentin, JD (reprint author), Childrens Hosp, Med Ctr, Div Mol Cardiovasc Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA |
Addresses:
1. Childrens Hosp, Med Ctr, Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA
2. Univ Texas, SW Med Ctr, Dept Mol Biol & Oncol, Dallas, TX 75235 USA
3. Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA
4. Univ Cincinnati, Dept Mol Genet, Cincinnati, OH 45267 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 118TR |
| ISSN: 0036-8075 |
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