| | |  | | | | Record from Web of Science® | | | | | | |
| Identification of germ-line E-cadherin mutations in gastric cancer families of European origin |
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| Author(s): Gayther SA, Gorringe KL, Ramus SJ, Huntsman D, Roviello F, Grehan N, Machado JC, Pinto E, Seruca R, Halling K, MacLeod P, Powell SM, Jackson CE, Ponder BAJ, Caldas C |
| Source: CANCER RESEARCH Volume: 58 Issue: 18 Pages: 4086-4089 Published: SEP 15 1998 |
| Times Cited: 179 References: 20 |
| Abstract: E-cadherin germ-line mutations have recently been described as a molecular basis for early-onset familial gastric cancer in Maori kindred. We screened 18 gastric cancer families of European origin for germ-line mutations to determine the proportion in which E-cadherin mutations occur and the clinical characteristics of the affected families. Truncating mutations were identified in three kindred with familial diffuse gastric cancer. In these families, the age of onset of gastric cancer was variable, the penetrance was incomplete, and one kindred contained individuals with cancers at other sites. Here, we show that a proportion of diffuse gastric cancer families of European origin have germ-line E-cadherin mutations; however, these mutations are absent in intestinal gastric cancer families. |
| Document Type: Article |
| Language: English |
| Reprint Address: Caldas, C (reprint author), Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 2QQ, England |
Addresses:
1. Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 2QQ, England
2. Univ Cambridge, Addenbrookes Hosp, Canc Res Campaign, Human Canc Genet Res Grp, Cambridge CB2 2QQ, England
3. Univ Siena, Ist Policattedra Sci Chirurg, I-53100 Siena, Italy
4. Univ Porto, IPATIMUP, Inst Patol & Imunol Mol, P-4200 Oporto, Portugal
5. Mayo Clin, Rochester, MN 55905 USA
6. Victoria Gen Hosp, Victoria, BC V8Z 6R5 Canada
7. Univ Virginia, Hlth Sci Ctr, Dept Internal Med, Charlottesville, VA 22906 USA
8. Henry Ford Hosp, Detroit, MI 48202 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA |
| Subject Category: Oncology |
| IDS Number: 120ZM |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |