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Semiconductor nanocrystals as fluorescent biological labels
Author(s): Bruchez M, Moronne M, Gin P, Weiss S, Alivisatos AP
Source: SCIENCE    Volume: 281    Issue: 5385    Pages: 2013-2016    Published: SEP 25 1998  
Times Cited: 2,632     References: 25     
Abstract: Semiconductor nanocrystals were prepared for use as fluorescent probes in biological staining and diagnostics. Compared with conventional fluorophores, the nanocrystals have a narrow, tunable. symmetric emission spectrum and are photochemically stable. The advantages of the broad, continuous excitation spectrum were demonstrated in a dual-emission, single-excitation labeling experiment on mouse fibroblasts. These nanocrystal probes are thus complementary and in some cases may be superior to existing fluorophores.
Document Type: Article
Language: English
Reprint Address: Weiss, S (reprint author), Univ Calif Berkeley, Lawrence Berkeley Lab, Div Mat Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA
Addresses:
1. Univ Calif Berkeley, Lawrence Berkeley Lab, Div Mat Sci, Berkeley, CA 94720 USA
2. Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
3. Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
4. Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USA
Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
Subject Category: Multidisciplinary Sciences
IDS Number: 124BV
ISSN: 0036-8075
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