| | |  | | | | Record from Web of Science® | | | | | | |
| Cellular mechanisms of cardiac hypertrophy |
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| Author(s): Sugden PH, Clerk A |
| Source: JOURNAL OF MOLECULAR MEDICINE-JMM Volume: 76 Issue: 11 Pages: 725-746 Published: OCT 1998 |
| Times Cited: 210 References: 307 |
| Abstract: Hypertrophy of myocytes in the heart ventricles is an important adaptation that in vivo occurs in response to a requirement for increased contractile power. It involves changes at the level of gene transcription, stimulation of the rate of protein synthesis (translation), and increased assembly of myofibrils. There is mounting evidence of the involvement of reversible protein phosphorylation and dephosphorylation in most of these processes. Protein kinase C, mitogen-activated protein kinases, and transcription factors have been implicated in the modulation of the transcriptional changes. Activation of translation may also be mediated through protein phosphorylation/dephosphorylation, although this has not been clearly established in the heart. Here we provide a critical overview of the signalling pathways involved in the hypertrophic response and provide a scheme to account for many of its features. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sugden, PH (reprint author), Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, Div Cardiac Med, Royal Brompton Campus,Dovehouse St, London SW3 6LY, England |
Addresses:
1. Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, Div Cardiac Med, London SW3 6LY, England
2. Univ London Imperial Coll Sci Technol & Med, Sch Med, Div Biomed Sci Mol Pathol, London SW6 2LZ, England |
| Publisher: SPRINGER VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 USA |
| Subject Category: Genetics & Heredity; Medicine, Research & Experimental |
| IDS Number: 127XJ |
| ISSN: 0946-2716 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |