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| A physical map of 30,000 human genes |
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| Author(s): Deloukas P, Schuler GD, Gyapay G, Beasley EM, Soderlund C, Rodriguez-Tome P, Hui L, Matise TC, McKusick KB, Beckmann JS, Bentolila S, Bihoreau MT, Birren BB, Browne J, Butler A, Castle AB, Chiannilkulchai N, Clee C, Day PJR, Dehejia A, Dibling T, Drouot N, Duprat S, Fizames C, Fox S, Gelling S, Green L, Harrison P, Hocking R, Holloway E, Hunt S, Keil S, Lijnzaad P, Louis-Dit-Sully C, Ma J, Mendis A, Miller J, Morissette J, Muselet D, Nusbaum HC, Peck A, Rozen S, Simon D, Slonim DK, Staples R, Stein LD, Stewart EA, Suchard MA, Thangarajah T, Vega-Czarny N, Webber C, Wu X, Hudson J, Auffray C, Nomura N, Sikela JM, Polymeropoulos MH, James MR, Lander ES, Hudson TJ, Myers RM, Cox DR, Weissenbach J, Boguski MS, Bentley DR |
| Source: SCIENCE Volume: 282 Issue: 5389 Pages: 744-746 Published: OCT 23 1998 |
| Times Cited: 519 References: 45 |
| Abstract: A map of 30,181 human gene-based markers was assembled and integrated with the current genetic map by radiation hybrid mapping. The new gene map contains nearly twice as many genes as the previous release, includes most genes that encode proteins of known function, and is twofold to threefold more accurate than the previous version. A redesigned, more informative and functional World Wide Web site (www.ncbi.nlm.nih.gov/genemap) provides the mapping information and associated data and annotations. This resource constitutes an important infrastructure and tool for the study of complex genetic traits, the positional cloning of disease genes, the cross-referencing of mammalian genomes, and validated human transcribed sequences for Large-scale studies of gene expression. |
| Document Type: Article |
| Language: English |
| Reprint Address: Deloukas, P (reprint author), Sanger Ctr, Hixton Hall, Cambridge CB10 1SA, England |
Addresses:
1. Sanger Ctr, Cambridge CB10 1SA, England
2. Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA
3. CNRS, URA 1922, F-91000 Evry, France
4. Stanford Univ, Sch Med, Stanford Human Genome Ctr, Dept Genet, Stanford, CA 94305 USA
5. European Bioinformat Inst, European Mol Biol Lab Outstn, Cambridge CB10 1SD, England
6. MIT, Whitehead Inst Biomed Res, Ctr Genome Res, Cambridge Ctr 9, Cambridge, MA 02142 USA
7. Rockefeller Univ, Lab Stat Genet, New York, NY 10021 USA
8. Genethon, CNRS, URA 1922, F-91000 Evry, France
9. Univ Oxford, Nuffield Dept Clin Med, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
10. NIH, Lab Genet Dis Res, Natl Ctr Human Genome Res, Bethesda, MD 20892 USA
11. CHU Laval, Ctr Rech, Quebec City, PQ G1V 4G2 Canada
12. Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
13. Univ Calif Los Angeles, Sch Med, Dept Biomath, Los Angeles, CA 90095 USA
14. Res Genet, Huntsville, AL 35801 USA
15. CNRS, UPR 420, F-94801 Villejuif, France
16. Kazusa DNA Res Inst, Chiba 292, Japan
17. Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA
18. Univ Colorado, Hlth Sci Ctr, Program Mol Biol, Denver, CO 80262 USA
19. MIT, Dept Biol, Cambridge, MA 02142 USA
20. McGill Univ, Montreal Gen Hosp, Res Inst, Montreal, PQ H3G 1A4 Canada |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 132AM |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |