| | |  | | | | Record from Web of Science® | | | | | | |
| Embryonic stem cell lines derived from human blastocysts |
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| Author(s): Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM |
| Source: SCIENCE Volume: 282 Issue: 5391 Pages: 1145-1147 Published: NOV 6 1998 |
| Times Cited: 2,271 References: 23 |
| Abstract: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages. After undifferentiated proliferation in vitro for 4 to 5 months, these cells still maintained the developmental potential to form trophoblast and derivatives of all three embryonic germ layers, including gut epithelium (endoderm); cartilage, bone, smooth muscle, and striated muscle (mesoderm); and neural epithelium, embryonic ganglia, and stratified squamous epithelium (ectoderm). These cell lines should be useful in human developmental biology, drug discovery, and transplantation medicine. |
| Document Type: Article |
| Language: English |
| Reprint Address: Thomson, JA (reprint author), Univ Wisconsin, Wisconsin Reg Primate Res Ctr, 1223 Capitol Court, Madison, WI 53715 USA |
Addresses:
1. Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA
2. Technion Israel Inst Technol, Fac Med, Dept Gynecol & Obstet, Rambam Med Ctr, IL-31096 Haifa, Israel
3. Univ Wisconsin, Dept Obstet & Gynecol, Madison, WI 53715 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 136YY |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |