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| No linkage or linkage disequilibrium between brain-derived neurotrophic factor (BDNF) dinucleotide repeat polymorphism and schizophrenia in Irish families |
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| Author(s): Hawi Z, Straub RE, O'Neill A, Kendler KS, Walsh D, Gill M |
| Source: PSYCHIATRY RESEARCH Volume: 81 Issue: 2 Pages: 111-116 Published: NOV 16 1998 |
| Times Cited: 43 References: 23 |
| Abstract: There is increasing evidence that a neurodevelopmental process is accountable for at least a proportion of schizophrenic cases. Brain-derived neurotrophic factor (BDNF), a member of a group of proteins that includes, neurotrophin-3/4/5 and nerve growth factor (NGF), is an attractive candidate gene. We have performed a case: control association study using the BDNF dinucleotide repeat polymorphism in a sample of familial schizophrenic individuals and in healthy, ethnically matched control subjects. We also performed a linkage analysis on 265 multiplex families using the same marker. We found no differences in allele frequencies between the patient and control groups nor any evidence for transmission disequilibrium or linkage with the multiply affected families. We conclude that DNA variation at or near the BDNF gene is unlikely to contribute to the genetic predisposition to schizophrenia. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hawi, Z (reprint author), Trinity Coll, Dept Psychiat & Genet, Lincoln Pl Gate, Dublin 2, Ireland |
Addresses:
1. Trinity Coll, Dept Psychiat & Genet, Dublin 2, Ireland
2. Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA USA
3. Queens Univ Belfast, Dept Psychiat, Belfast, Antrim North Ireland
4. Hlth Res Board, Dublin, Ireland |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Psychiatry |
| IDS Number: 143CZ |
| ISSN: 0165-1781 |
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