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| De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin |
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| Author(s): Gat U, DasGupta R, Degenstein L, Fuchs E |
| Source: CELL Volume: 95 Issue: 5 Pages: 605-614 Published: NOV 25 1998 |
| Times Cited: 539 References: 43 |
| Abstract: An effector of intercellular adhesion, beta-catenin also functions in Wnt signaling, associating with Lef-1/Tcf DNA-binding proteins to form a transcription factor. We report that this pathway operates in keratinocytes and that mice expressing a stabilized beta-catenin controlled by an epidermal promoter undergo a process resembling de novo hair morphogenesis. The new follicles formed sebaceous glands and dermal papilla, normally established only in embryogenesis. As in embryologically initiated hair germs, transgenic follicles induce Lef-1, but follicles are disoriented and defective in sonic hedgehog polarization. Additionally, proliferation continues unchecked, resulting in two types of tumors also found in humans. Our findings suggest that transient beta-catenin stabilization may be a key player in the long-sought epidermal signal reading to hair development and implicate aberrant beta-catenin activation in hair tumors. |
| Document Type: Article |
| Language: English |
| Reprint Address: Fuchs, E (reprint author), Univ Chicago, Howard Hughes Med Inst, 5841 S Maryland Ave, Chicago, IL 60637 USA |
Addresses:
1. Univ Chicago, Howard Hughes Med Inst, Chicago, IL 60637 USA
2. Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA
3. Univ Chicago, Comm Dev Biol, Chicago, IL 60637 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 143KD |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |