| | |  | | | | Record from Web of Science® | | | | | | |
| Comparison of the complete protein sets of worm and yeast: Orthology and divergence |
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| Author(s): Chervitz SA, Aravind L, Sherlock G, Ball CA, Koonin EV, Dwight SS, Harris MA, Dolinski K, Mohr S, Smith T, Weng S, Cherry JM, Botstein D |
| Source: SCIENCE Volume: 282 Issue: 5396 Pages: 2022-2028 Published: DEC 11 1998 |
| Times Cited: 305 References: 40 |
| Abstract: Comparative analysis of predicted protein sequences encoded by the genomes of Caenorhabditis elegans and Saccharomyces cerevisiae suggests that most of the core biological functions are carried out by orthologous proteins (proteins of different species that can be traced back to a common ancestor) that occur in comparable numbers. The specialized processes of signal transduction and regulatory control that are unique to the multicellular worm appear to use novel proteins, many of which re-use conserved domains. Major expansion of the number of some of these domains seen in the worm may have contributed to the advent of multicellularity, The proteins conserved in yeast and worm are Likely to have orthologs throughout eukaryotes; in contrast, the proteins unique to the worm may well define metazoans. |
| Document Type: Review |
| Language: English |
| Reprint Address: Chervitz, SA (reprint author), Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA |
Addresses:
1. Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
2. NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA
3. Boston Univ, Dept Biomed Engn, Boston, MA 02115 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 147BB |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |