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| LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons |
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| Author(s): Sharma K, Sheng HZ, Lettieri K, Li H, Karavanov A, Potter S, Westphal H, Pfaff SL |
| Source: CELL Volume: 95 Issue: 6 Pages: 817-828 Published: DEC 11 1998 |
| Times Cited: 228 References: 55 |
| Abstract: The circuits that control movement are comprised of discrete subtypes of motor neurons. How motor neuron subclasses develop and extend axons to their correct targets is still poorly understood. We show that LIM homeodomain factors Lhx3 and Lhx4 are expressed transiently in motor neurons whose axons emerge ventrally from the neural tube (V-MN). Motor neurons develop in embryos deficient in both Lhx3 and Lhx4, but v-MN cells switch their subclass identity to become motor neurons that extend axons dorsally from the neural tube (d-MN). Conversely, the misexpression of Lhx3 in dorsal-exiting motor neurons is sufficient to reorient their axonal projections ventrally. Thus, Lhx3 and Lhx4 act in a binary fashion during a brief period in development to specify the trajectory of motor axons from the neural tube. |
| Document Type: Article |
| Language: English |
| Reprint Address: Pfaff, SL (reprint author), Salk Inst, Gene Express Lab, La Jolla, CA 92037 USA |
Addresses:
1. Salk Inst, Gene Express Lab, La Jolla, CA 92037 USA
2. NICHHD, Lab Mammalian Genet & Dev, Bethesda, MD 20892 USA
3. NICHHD, Mol Genet Lab, Bethesda, MD 20892 USA
4. Acad Sinica, Inst Mol Biol, Taipei, Taiwan
5. Childrens Hosp, Cincinnati, OH 45229 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 148HG |
| ISSN: 0092-8674 |
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