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| Prevalence of the I1307K APC gene variant in Israeli Jews of differing ethnic origin and risk for colorectal cancer |
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| Author(s): Rozen P, Shomrat R, Strul H, Naiman T, Karminsky N, Legum C, Orr-Urtreger A |
| Source: GASTROENTEROLOGY Volume: 116 Issue: 1 Pages: 54-57 Published: JAN 1999 |
| Times Cited: 44 References: 14 |
| Abstract: Background & Aims: Israeli Jews of European birth, i.e., Ashkenazim, have the highest colorectal cancer incidence of any Israeli ethnic group. The I1307K APC gene variant was found in 6.1% of American Jews, 28% of their familial colorectal cancer cases, but not in non-Jews. We assessed the I1307K prevalence in Israeli Jews of differing ethnic origin and risk for colorectal cancer. Methods: DNA samples from 500 unrelated Jews of European or non-European origin, with or without a personal and/or family history of neoplasia, were examined for the I1307K variant by the allele-specific oligonucleotide (ASO) method. Results: In persons at average risk for colorectal cancer, I1307K was found in 5.0% of 120 European and 1.6% of 188 non-European Jews (P = 0.08). It occurred in 15.4% of 52 Ashkenazi Israelis with familial cancer (P = 0.02) and was not detected in 51 non-European Jews at increased cancer risk. Colorectal neoplasia occurred personally or in the families of 13 of 20 Ashkenazi I1307K carriers, 8 of whom also had a personal or family history of noncolonic neoplasia. Conclusions: The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis. |
| Document Type: Article |
| Language: English |
| Reprint Address: Rozen, P (reprint author), Tel Aviv Med Ctr, Dept Gastroenterol, 6 Weizman St, IL-64239 Tel Aviv, Israel |
Addresses:
1. Tel Aviv Med Ctr, Dept Gastroenterol, IL-64239 Tel Aviv, Israel
2. Tel Aviv Med Ctr, Dept Genet, IL-64239 Tel Aviv, Israel
3. Tel Aviv Med Ctr, Dept Oncol, IL-64239 Tel Aviv, Israel
4. Tel Aviv Univ, Sch Med, IL-69978 Tel Aviv, Israel |
| Publisher: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA |
| Subject Category: Gastroenterology & Hepatology |
| IDS Number: 152PG |
| ISSN: 0016-5085 |
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