| | |  | | | | Record from Web of Science® | | | | | | |
| New insights into the role of nuclear factor-kappa B, a ubiquitous transcription factor in the initiation of diseases |
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| Author(s): Chen F, Castranova V, Shi XL, Demers LM |
| Source: CLINICAL CHEMISTRY Volume: 45 Issue: 1 Pages: 7-17 Published: JAN 1999 |
| Times Cited: 316 References: 116 |
| Abstract: Nuclear factor-kappa B (NF-kappa B) is a ubiquitous transcription factor that governs the expression of genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-kappa B is activated by several agents, including cytokines, oxidant free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases. |
| Document Type: Review |
| Language: English |
| Reprint Address: Chen, F (reprint author), NIOSH, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV 26505 USA |
Addresses:
1. NIOSH, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV 26505 USA
2. Penn State Univ, Coll Med, Dept Pathol, Hershey, PA 17033 USA |
| Publisher: AMER ASSOC CLINICAL CHEMISTRY, 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA |
| Subject Category: Medical Laboratory Technology |
| IDS Number: 157AU |
| ISSN: 0009-9147 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |