| | |  | | | | Record from Web of Science® | | | | | | |
| De novo reconstitution of a functional mammalian urinary bladder by tissue engineering |
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| Author(s): Oberpenning F, Meng J, Yoo JJ, Atala A |
| Source: NATURE BIOTECHNOLOGY Volume: 17 Issue: 2 Pages: 149-155 Published: FEB 1999 |
| Times Cited: 252 References: 35 |
| Abstract: Human organ replacement is limited by a donor shortage, problems with tissue compatibility, and rejection. Creation of an organ with autologous tissue would be advantageous. In this study, transplantable urinary bladder neo-organs were reproducibly created in vitro from urothelial and smooth muscle cells grown in culture from canine native bladder biopsies and seeded onto preformed bladder-shaped polymers. The native bladders were subsequently excised from canine donors and replaced with the tissue-engineered neo-organs. In functional evaluations for up to 11 months, the bladder neo-organs demonstrated a normal capacity to retain urine, normal elastic properties, and histologic architecture. This study demonstrates, for the first time, that successful reconstitution of an autonomous hollow organ is possible using tissue-engineering methods. |
| Document Type: Article |
| Language: English |
| Reprint Address: Atala, A (reprint author), Childrens Hosp, Dept Urol, Lab Tissue Engn & Cellular Therapeut, 300 Longwood Ave, Boston, MA 02115 USA |
Addresses:
1. Childrens Hosp, Dept Urol, Lab Tissue Engn & Cellular Therapeut, Boston, MA 02115 USA
2. Harvard Univ, Sch Med, Boston, MA USA |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Biotechnology & Applied Microbiology |
| IDS Number: 165EX |
| ISSN: 1087-0156 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |