| The oncogenic activation of beta-catenin |
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| Author(s): Polakis P |
| Source: CURRENT OPINION IN GENETICS & DEVELOPMENT Volume: 9 Issue: 1 Pages: 15-21 Published: FEB 1999 |
| Times Cited: 380 References: 71 |
| Abstract: The activation of beta-catenin to an oncogenic state can result from the inactivation of the tumor suppressor adenomatous polyposis coil (APC), by direct mutation in the beta-catenin gene, or by the activation of wnt receptors. Once activated, beta-catenin mast likely promotes tumor progression through its persistent interaction with one or more of its numerous downstream targets. |
| Document Type: Article |
| Language: English |
| Reprint Address: Polakis, P (reprint author), Onyx Pharmaceut, 3031 Res Dr, Richmond, CA 94806 USA |
Addresses:
1. Onyx Pharmaceut, Richmond, CA 94806 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology; Genetics & Heredity |
| IDS Number: 167CT |
| ISSN: 0959-437X |