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| Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia II. Systemic but not local IgA responses correlate with clearance of HPV-16 |
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| Author(s): Bontkes HJ, de Gruijl TD, Walboomers JMM, Schiller JT, Dillner J, Helmerhorst TJM, Verheijen RHM, Scheper RJ, Meijer CJLM |
| Source: JOURNAL OF GENERAL VIROLOGY Volume: 80 Pages: 409-417 Part: Part 2 Published: FEB 1999 |
| Times Cited: 64 References: 24 |
| Abstract: To investigate whether there is an association between local or systemic IgG and IgA responses against human papillomavirus (HPV) type 16 virus-like particles (VLP) containing L1 and L2 and the possible influence of these responses on clearance of HPV-16 and its associated lesions, cervical mucus samples from 125 patients and plasma samples from 100 patients, all participating in a non-intervention cohort study of women with abnormal cytology, were analysed. The results show that local IgG and IgA HPV-16 VLP-specific antibodies do not correlate with virus clearance, However, systemic IgG responses were more frequently detected in patients with a persistent infection (11/24) compared with patients with cleared HPV-16 infections (3/28, P= 0.006). Furthermore, the ultimate development of high-grade lesions was associated with systemic VLP-specific IgG reactivity (P = 0.026). By contrast, systemic IgA responses were correlated with virus clearance (7/28 clearance compared with 1/24 persistence patients, P = 0.06). This correlation was statistically significant when only those clearance patients who tested HPV-16 DNA-positive at more than one visit were included in the analysis (5/11 compared with 1/24, P = 0.007), As these systemic IgA responses were not accompanied by local IgA responses, the systemic IgA responses in HPV-16 clearance patients are suggested to be a by-product of a successful cellular immune response induced at the local lymph nodes, mediated by cytokines. |
| Document Type: Article |
| Language: English |
| Reprint Address: Walboomers, JMM (reprint author), Free Univ Amsterdam Hosp, Dept Pathol, POB 7057, NL-1007 MB Amsterdam, Netherlands |
Addresses:
1. Free Univ Amsterdam Hosp, Dept Pathol, NL-1007 MB Amsterdam, Netherlands
2. Free Univ Amsterdam Hosp, Dept Obstet & Gynaecol, NL-1007 MB Amsterdam, Netherlands
3. NCI, Cellular Oncol Lab, Div Basic Sci, Bethesda, MD 20892 USA
4. Karolinska Inst, Ctr Microbiol & Tumor Biol, Stockholm, Sweden |
| Publisher: SOC GENERAL MICROBIOLOGY, MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING, BERKS, ENGLAND RG7 1AE |
| Subject Category: Biotechnology & Applied Microbiology; Virology |
| IDS Number: 168MM |
| ISSN: 0022-1317 |
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