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| Determination of high mobility group I(Y) expression level in colorectal neoplasias: A potential diagnostic marker |
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| Author(s): Abe N, Watanabe T, Sugiyama M, Uchimura H, Chiappetta G, Fusco A, Atomi Y |
| Source: CANCER RESEARCH Volume: 59 Issue: 6 Pages: 1169-1174 Published: MAR 15 1999 |
| Times Cited: 66 References: 28 |
| Abstract: High mobility group I(Y) [HMGI(Y)] proteins are architectural factors abundantly expressed during embryogenesis, and their overexpression is known to be closely associated with neoplastic transformation of cells. This study was performed to investigate whether determination of HMGI(Y) expression level could assist in (a) differential diagnosis between colorectal carcinoma, adenoma, and normal tissue and (b) determination of the prognosis of patients with colorectal cancer. To this end, HMGI(Y) expression was determined at both the protein and mRNA levels in 30 colorectal carcinomas, 26 adenomas, and 23 normal mucosa samples, and further correlations between the protein expression levels and various clinicopathological parameters, such as depth of tumor invasion, lymphatic and/or venous involvement, regional Lymph node metastasis, and Dukes' stage, were determined in 30 carcinoma cases, The expression of HMGI(Y) proteins was significantly increased in carcinoma and adenoma with severe atypia compared with that in adenoma with less atypia and normal colorectal mucosa. This increase in HMGI(Y) protein expression was found to be because of an increase in its mRNA expression by RNA in situ hybridization analysis. Clinicopathological analysis revealed that the level of HMGI(Y) protein expression was significantly correlated with parameters known to be indicative of a poor prognosis in colorectal cancer patients. These findings indicate that the determination of the HMGI(Y) protein expression level could be a potential marker for the diagnosis of colorectal neoplasias and can be of great value in predicting the prognosis of patients with colorectal cancer. |
| Document Type: Article |
| Language: English |
| Reprint Address: Abe, N (reprint author), Kyorin Univ, Sch Med, Dept Surg 1, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611 Japan |
Addresses:
1. Kyorin Univ, Sch Med, Dept Surg 1, Mitaka, Tokyo 1818611 Japan
2. Kyorin Univ, Sch Med, Dept Clin Pathol, Mitaka, Tokyo 1818611 Japan
3. Fdn Senatore Pascale, Inst Nazl Tumori Napoli, I-80131 Naples, Italy
4. Univ Reggio Calabria, Fac Med & Chirurg Catanzaro, Dipartimento Med Sperimentale & Clin, I-88100 Cantanzaro, Italy |
| Publisher: AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA |
| Subject Category: Oncology |
| IDS Number: 175ZD |
| ISSN: 0008-5472 |
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