| | |  | | | | Record from Web of Science® | | | | | | |
| Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity |
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| Author(s): Bhat MA, Izaddoost S, Lu Y, Cho KO, Choi KW, Bellen HJ |
| Source: CELL Volume: 96 Issue: 6 Pages: 833-845 Published: MAR 19 1999 |
| Times Cited: 163 References: 43 |
| Abstract: Polarization of epithelial cells depends on a hierarchical process whereby specific membrane-associated proteins become targeted to specialized membrane domains. Here, we describe a novel Drosophila protein, Discs Lost (DLT), that plays a crucial role in the polarization of embryonic epithelia during cellular blastoderm formation. At subsequent stages of development, DLT interacts with the apical determinant Crumbs (CRB) and the laterally localized protein Neurexin IV (NRX IV). Mutations in dlt or double-stranded RNA interference lead to aberrant localization of CRB and NRX IV and cause a concomitant loss of epithelial cell polarity. Hence, DLT is required to establish and maintain cell polarity and participates in different molecular complexes that define apical and lateral membrane domains. |
| Document Type: Article |
| Language: English |
| Reprint Address: Bellen, HJ (reprint author), Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA |
Addresses:
1. Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA
2. Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
3. Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA
4. Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 178ZY |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |