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| The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis |
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| Author(s): Ghiglione C, Carraway KL, Amundadottir LT, Boswell RE, Perrimon N, Duffy JB |
| Source: CELL Volume: 96 Issue: 6 Pages: 847-856 Published: MAR 19 1999 |
| Times Cited: 122 References: 59 |
| Abstract: We have identified the Drosophila transmembrane molecule kekkon 1 (kek1) as an inhibitor of the epidermal growth factor receptor (EGFR) and demonstrate that it acts in a negative feedback loop to modulate the activity of the EGFR tyrosine kinase. During oogenesis, kek1 is expressed in response to the Gurken/EGFR signaling pathway, and loss of kek1 activity is associated with an increase in EGFR signaling. Consistent with our loss-of-function studies, we demonstrate that ectopic overexpression of kek1 mimics a loss of EGFR activity. We show that the extracellular and transmembrane domains of Kek1 can inhibit and physically associate with the EGFR, suggesting potential models for this inhibitory mechanism. |
| Document Type: Article |
| Language: English |
| Reprint Address: Perrimon, N (reprint author), Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA |
Addresses:
1. Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
2. Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
3. Beth Israel Med Ctr, Div Signal Transduct, Boston, MA 02115 USA
4. Univ Colorado, Howard Hughes Med Inst, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 178ZY |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |