| | |  | | | | Record from Web of Science® | | | | | | |
| New concepts in tissue specificity for prostate cancer and benign prostatic hyperplasia |
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| Author(s): De Marzo AM, Coffey DS, Nelson WG |
| Source: UROLOGY Volume: 53 Issue: 3 Pages: 29-40 Supplement: Suppl. S Published: MAR 1999 |
| Times Cited: 61 References: 123 |
| Abstract: Of the hundreds of species of mammals, all of which have prostate glands, only humans and dogs are known to suffer from benign prostatic hyperplasia (BPH) and prostate carcinoma. In humans, prostate carcinoma is common, yet carcinomas of other sex accessory tissues are rare. In addition, different anatomic regions within the prostate gland have very different rates of BPH and carcinoma. In this article, we explore ideas and potential mechanisms relating to these paradoxical findings that may help explain the species, organ, and zone specificity of BPH and prostate cancer. We present an evolutionary argument that attempts to relate a high-fat diet, with its potential for generating oxidative DNA damage, to the species selectivity of prostate cancer. In addition, we outline an argument based on our preliminary studies indicating that chronic inflammation and the associated increase in cell turnover in the setting of increased oxidative stress may help to account for the organ selectivity of genitourinary carcinomas. (C) 1999, Elsevier Science Inc. All rights reserved. |
| Document Type: Review |
| Language: English |
| Reprint Address: De Marzo, AM (reprint author), Johns Hopkins Univ, Inst Med, Dept Pathol, Ross 512B,720 Rutland Ave, Baltimore, MD 21205 USA |
Addresses:
1. Johns Hopkins Univ, Inst Med, Dept Pathol, Baltimore, MD 21205 USA
2. Johns Hopkins Univ, Inst Med, James Buchanan Brady Urol Inst, Baltimore, MD USA
3. Johns Hopkins Univ, Inst Med, Ctr Oncol, Baltimore, MD USA |
| Publisher: ELSEVIER SCIENCE INC, 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA |
| Subject Category: Urology & Nephrology |
| IDS Number: 179CF |
| ISSN: 0090-4295 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |