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| Regulation of maternal behavior and offspring growth by paternally expressed Peg3 |
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| Author(s): Li LL, Keverne EB, Aparicio SA, Ishino F, Barton SC, Surani MA |
| Source: SCIENCE Volume: 284 Issue: 5412 Pages: 330-333 Published: APR 9 1999 |
| Times Cited: 193 References: 26 |
| Abstract: Imprinted genes display parent-of-origin-dependent monoallelic expression that apparently regulates complex mammalian traits, including growth and behavior. The Peg3 gene is expressed in embryos and the adult brain from the paternal allele only. A mutation in the Peg3 gene resulted in growth retardation, as well as a striking impairment of maternal behavior that frequently resulted in death of the offspring. This result may be partly due to defective neuronal connectivity, as well as reduced oxytocin neurons in the hypothalamus, because mutant mothers were deficient in milk ejection. This study provides further insights on the evolution of epigenetic regulation of imprinted gene dosage in modulating mammalian growth and behavior. |
| Document Type: Article |
| Language: English |
| Reprint Address: Surani, MA (reprint author), Univ Cambridge, Wellcome CRC Inst Canc & Dev Biol, Tennis Court Rd, Cambridge CB2 1QR, England |
Addresses:
1. Univ Cambridge, Wellcome CRC Inst Canc & Dev Biol, Cambridge CB2 1QR, England
2. Univ Cambridge, Physiol Lab, Cambridge CB2 1QR, England
3. Univ Cambridge, Subdept Anim Behav, Cambridge CB3 8AA, England
4. Tokyo Inst Technol, Ctr Gene Res, Midori Ku, Yokohama, Kanagawa 226 Japan |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 184WH |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |