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| Hepatitis C virus is related to progressive liver disease in human immunodeficiency virus-positive hemophiliacs and should be treated as an opportunistic infection |
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| Author(s): Lesens O, Deschenes M, Steben M, Belanger G, Tsoukas CM |
| Source: JOURNAL OF INFECTIOUS DISEASES Volume: 179 Issue: 5 Pages: 1254-1258 Published: MAY 1999 |
| Times Cited: 132 References: 14 |
| Abstract: The hypothesis was investigated that hepatitis C virus (HCV) infection behaves like an opportunistic infection in which progressive liver disease (PLD) is the principal manifestation. PLD in 81 hemophiliacs coinfected with HCV and human immunodeficiency virus (HIV) was compared with 53 HIV-seronegative HCV-infected hemophiliacs. Progression to AIDS and death in 22 HCV/HIV-coinfected hemophiliacs with PLD was also compared with 59 coinfected hemophiliacs who did not develop PLD, The risk of PLD occurrence associated with an HIV-positive status was 7.4 (95% confidence interval [CI], 2.2-25.5; Cox model). In the coinfected group, the risk of PLD occurrence was higher in subjects with severe AIDS-defining immunodeficiency than in those without (odds ratio, 3.6; 95% CI, 1.3-10), Persons with PLD also had a faster progression to AIDS (P = .03, log rank test) than those without PLD, Thus, as with other chronic resident human viruses, HCV should be considered another opportunistic pathogen in HIV disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: Lesens, O (reprint author), Montreal Gen Hosp, Immune Deficiency Treatment Ctr, 1650 Cedar Ave,Room A5-145, Montreal, PQ H3G 1A4 Canada |
Addresses:
1. Montreal Gen Hosp, Immune Deficiency Treatment Ctr, Montreal, PQ H3G 1A4 Canada
2. Publ Hlth Direct, Infect Dis Unit, Montreal, PQ Canada
3. Royal Victoria Hosp, Dept Gastroenterol, Montreal, PQ Canada
4. Montreal Childrens Hosp, Montreal, PQ H3H 1P3 Canada |
| Publisher: UNIV CHICAGO PRESS, 5720 SOUTH WOODLAWN AVE, CHICAGO, IL 60637-1603 USA |
| Subject Category: Infectious Diseases |
| IDS Number: 189TQ |
| ISSN: 0022-1899 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |