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| Crippling of CD3-zeta ITAMs does not impair T cell receptor signaling |
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| Author(s): Ardouin L, Boyer C, Gillet A, Trucy J, Bernard AM, Nunes J, Delon J, Trautmann A, He HT, Malissen B, Malissen M |
| Source: IMMUNITY Volume: 10 Issue: 4 Pages: 409-420 Published: APR 1999 |
| Times Cited: 70 References: 46 |
| Abstract: We evaluated the importance of CD3-zeta ITAMs in T cell responses by breeding the P14 transgenic TCR into mice in which CD3-zeta chains lacking all or part of their ITAMs were genetically substituted for wild-type CD3-zeta chains. In contrast to the H-Y TCR, the P14 ICR permitted the development of peripheral CD8(+) T cells harboring signaling-defective CD3-zeta subunits. The absence of functional CD3-zeta ITAMs did not reduce the spectrum of activation events and effector functions that constitute the normal attributes of mature CD8(+) T cells. The only detectable differences were quantitative and noted only when T cells were challenged with suboptimal peptide concentrations. Therefore, the ITAMs present in the CD3-gamma delta epsilon module are sufficient for qualitatively normal TCR signaling and those present in CD3-zeta have no exclusive role during T cell activation. |
| Document Type: Article |
| Language: English |
| Reprint Address: Malissen, M (reprint author), CNRS Marseille Luminy, Ctr Immunol, INSERM, Case 906, F-13288 Marseille 9, France |
Addresses:
1. CNRS Marseille Luminy, Ctr Immunol, INSERM, F-13288 Marseille 9, France
2. CERVI, UMR CNRS 7627, Lab Immunol Cellulaire, F-75013 Paris, France |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Immunology |
| IDS Number: 190XB |
| ISSN: 1074-7613 |
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