| | |  | | | | Record from Web of Science® | | | | | | |
| PAS domains: Internal sensors of oxygen, redox potential, and light |
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| Author(s): Taylor BL, Zhulin IB |
| Source: MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS Volume: 63 Issue: 2 Pages: 479-+ Published: JUN 1999 |
| Times Cited: 693 References: 268 |
| Abstract: PAS domains are newly recognized signaling domains that are widely distributed in proteins fr-om members of the Archaea and Bacteria and from fungi, plants, insects, and vertebrates. They function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli. Specificity in sensing arises, in part from different cofactors that may be associated with the PAS fold. Transduction of redox signals may be a common mechanistic theme in many different PAS domains. PAS proteins are always located intracellularly monitor the external as well as the internal environment. One way in which prokaryotic PAS proteins sense the environment is by detecting changes in the electron transport system. This serves as an early warning system for any reduction in cellular energy levels. Human PAS proteins include hypoxia-inducible factors and voltage-sensitive ion channels; other PAS proteins are integral components of circadian clocks. Although PAS domains were only recently identified, the signaling function with which they are associated have long been recognised as fundamental properties of living cells. |
| Document Type: Review |
| Language: English |
| Reprint Address: Taylor, BL (reprint author), Loma Linda Univ, Sch Med, Dept Microbiol & Mol Genet, Loma Linda, CA 92350 USA |
Addresses:
1. Loma Linda Univ, Sch Med, Dept Microbiol & Mol Genet, Loma Linda, CA 92350 USA
2. Loma Linda Univ, Sch Med, Ctr Mol Biol & Gene Therapy, Loma Linda, CA 92350 USA |
| Publisher: AMER SOC MICROBIOLOGY, 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 USA |
| Subject Category: Microbiology |
| IDS Number: 203CV |
| ISSN: 1092-2172 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |