| | |  | | | | Record from Web of Science® | | | | | | |
| Preventing neurodegeneration in the Drosophila mutant bubblegum |
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| Author(s): Min KT, Benzer S |
| Source: SCIENCE Volume: 284 Issue: 5422 Pages: 1985-1988 Published: JUN 18 1999 |
| Times Cited: 88 References: 21 |
| Abstract: The Drosophila melanogaster recessive mutant bubblegum (bgm) exhibits adult neurodegeneration, with marked dilation of photoreceptor axons. The bubblegum mutant shows elevated levels of very long chain fatty acids (VLCFAs), as seen in the human disease adrenoleukodystrophy (ALD). In ALD, the excess can be lowered by dietary treatment with "Lorenzo's oil," a mixture of unsaturated fatty acids. Feeding the fly mutant one of the components, glyceryl trioleate oil, blocked the accumulation of excess VLCFAs as well as development of the pathology. Mutant flies thus provide a potential model system for studying mechanisms of neurodegenerative disease and screening drugs for treatment. |
| Document Type: Article |
| Language: English |
| Reprint Address: Benzer, S (reprint author), CALTECH, Div Biol 156 29, Pasadena, CA 91125 USA |
Addresses:
1. CALTECH, Div Biol 156 29, Pasadena, CA 91125 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 207JA |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |