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| Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations |
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| Author(s): Marsh S, Collie-Duguid ESR, Li T, Liu XH, McLeod HL |
| Source: GENOMICS Volume: 58 Issue: 3 Pages: 310-312 Published: JUN 15 1999 |
| Times Cited: 116 References: 11 |
| Abstract: Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target of cancer chemotherapy. A tandem repeat sequence in a TS promoter enhancer region (TSER) was recently identified. Polymorphic variation affected in vitro expression levels of the gene. We evaluated the influence of ethnicity on TSER genotype. Allele frequency was similar in Caucasian and Southwest Asian subjects. However, homozygous triple repeat subjects were tn-ice as common in Chinese subjects (67%) than in Caucasian subjects (38%). This demonstrates significant ethnic variation in a TS gene regulatory element which may have significant impact on pyrimidine homeostasis and drug therapy. (C) 1999 Academic Press. |
| Document Type: Article |
| Language: English |
| Reprint Address: McLeod, HL (reprint author), Univ Aberdeen, Inst Med Sci, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland |
Addresses:
1. Univ Aberdeen, Inst Med Sci, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland
2. Inst Psychiat, Mol Genet Sect, London SE5 8AF, England
3. W China Univ Med Sci, Chengdu 610041, Sichuan Peoples R China |
| Publisher: ACADEMIC PRESS INC, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA |
| Subject Category: Biotechnology & Applied Microbiology; Genetics & Heredity |
| IDS Number: 211FH |
| ISSN: 0888-7543 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |