| | |  | | | | Record from Web of Science® | | | | | | |
| Regional specialization in the mucosal immune system: primed cells do not always home along the same track |
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| Author(s): Brandtzaeg P, Farstad IN, Haraldsen G |
| Source: IMMUNOLOGY TODAY Volume: 20 Issue: 6 Pages: 267-277 Published: JUN 1999 |
| Times Cited: 162 References: 111 |
| Abstract: According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha(4)beta(7), which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Brandtzaeg, P (reprint author), Univ Oslo, Natl Hosp, Inst Pathol, LIPAT, N-0027 Oslo, Norway |
Addresses:
1. Univ Oslo, Natl Hosp, Inst Pathol, LIPAT, N-0027 Oslo, Norway |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 222JG |
| ISSN: 0167-5699 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |