| | |  | | | | Record from Web of Science® | | | | | | |
| Pathobiology of ischaemic stroke: an integrated view |
|
|
| Author(s): Dirnagl U, Iadecola C, Moskowitz MA |
| Source: TRENDS IN NEUROSCIENCES Volume: 22 Issue: 9 Pages: 391-397 Published: SEP 1999 |
| Times Cited: 940 References: 86 |
| Abstract: Brain injury following transient or permanent focal cerebral ischaemia (stroke) develops from a complex series of pathophysiological events that evolve in time and space. In this article, the relevance of excitotoxicity, peri-infarct depolarizations, inflammation and apoptosis to delayed mechanisms of damage within the peri-infarct zone or ischaemic penumbra are discussed. While focusing on potentially new avenues of treatment, the issue of why many clinical stroke trials have so far proved disappointing is addressed. This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain. |
| Document Type: Review |
| Language: English |
| Reprint Address: Dirnagl, U (reprint author), Charite Hosp, Dept Neurol, D-10098 Berlin, Germany |
Addresses:
1. Charite Hosp, Dept Neurol, D-10098 Berlin, Germany
2. Univ Minnesota, Sch Med, Lab Cerebrovasc Biol & Stroke, Dept Neurol, Minneapolis, MN 55455 USA
3. Harvard Univ, Sch Med, Stroke Res Lab, Massachusetts Gen Hosp, Charlestown, MA 02129 USA
4. Harvard Univ, Sch Med, Neurosurg Serv, Massachusetts Gen Hosp, Charlestown, MA 02129 USA
5. Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Charlestown, MA 02129 USA
6. Massachusetts Gen Hosp, Charlestown, MA 02129 USA |
| Publisher: ELSEVIER SCIENCE LONDON, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Neurosciences |
| IDS Number: 226LQ |
| ISSN: 0166-2236 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |